Computer-Aided Design of an Epitope-Based Vaccine against Epstein-Barr Virus

Figure 2

Structural mapping of predicted B cell epitopes in EBV envelope proteins. (a) KLPHWTPTLH in EBV gp42 3D structure (PDB: 3FD4 chain A); epitope shown as sticks and gp42 region interaction with HLA-DR is shown in red. (b) NTTVGIELPDA and (c) SSHGDLFRFSSDIQCP at EBV gB 3D structure (PDB: 3FVC) map, respectively, in its domain II and domain III; epitopes shown as sticks. (d) FSVEDLFGAN at gL 3D structure (PDB: 5T1D chain B) in its domain I (colored in blue); gH is colored in pale green. In (b, c, d), the corresponding whole structure is shown minimized at the bottom left of each panel; the magnified epitope mapping region is circled in them. In (a, b, c), the protein backbone is featured as pale green ribbon. Figures were rendered using PyMOL.

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