Journal of Immunology Research

Research Article

Computer-Aided Design of an Epitope-Based Vaccine against Epstein-Barr Virus

Table 4

Predicted conserved B cell epitopes from EBV envelope proteins.


Epitope	Antigen (gene)	Accession number¹	PDB²	Flex.³	Acc. (%)⁴	BLAST hit HMP (%)⁵	BLAST hit human (%)⁶

KLPHWTPTLH	gp42 (BZLF2)	P03205	3FD4:A [45–54]	2.256	80.0	EJZ65106.1 (70.00)	AAH22472.1 (60.00)
NTTVGIELPDA	gpB (BALF4)	P03188	3FVC [307–317]	1.890	67.0	EHM53795.1 (72.73)	XP_011519547.1 (63.64)
SSHGDLFRFSSDIQCP	gpB (BALF4)	P03188	3FVC [32–47]	1.369	69.8	KGF26221.1 (50.00)	XP_011520599.1 (50.00)
FSVEDLFGAN	gL (BKRF2)	P03212	5T1D:B [95–104]	1.505	53.1	EKB09257.1 (65.00)	XP_005271219.1 (70.00)

¹Accession number from the UniProtKB database. ²Epitope location in their corresponding PDBs is shown in brackets. The specific chain is indicated along with the PDB code. ³Values of flexibility (arbitrary units) and ⁴solvent accessibility (%) were calculated as explained in Materials and Methods. ^5,6Accession number of closest epitope BLAST hit in human microbiome proteins and human proteins, respectively (percentage of identity in parenthesis).