Serum Cytokine Levels and Their Relation to Clinical Features in Patients with Autoimmune Liver Diseases

Table 2

Serum circulating levels of cytokines in patients with AILD and in healthy controls. Numbers are presented as median (range).

	IL-2, pg/mL	IL-4, pg/mL	IL-6, pg/mL	IL-8, pg/mL	IL-10, pg/mL	IFN-γ, IU/mL	TNF-α, pg/mL
AILD ()	2.07 (0.11–111.87)	0.18 (0.11–1.25)	0.70 (0.17–99.86)	1.66 (0.45–34.58)	0.57 (0.11–951.96)	4.77 (0.59–493.96)	2.61 (0.23–120.88)
AIH ()	2.33 (0.19–41.33)	0.18 (0.11–0.34)	1.14 (0.20–19.4)	1.50 (0.45–34.58)	0.62 (0.22–29.94)	4.60 (0.59–133.32)	2.38 (0.56–52.96)
Overlap syndrome ()	1.97 (0.11–111.87)	0.18 (0.12–1.25)	0.60 (0.17–99.86)	2.15 (0.60–27.60)	0.52 (0.11–951.96)	5.12 (1.54–493.96)	2.66 (0.23–120.88)
Control ()	2.76 (0.45–4.10)	0.17 (0.11–0.53)	0.40 (0.14–2.65)	0.53 (0.35–2.38)	0.42 (0.13–51.67)	5.65 (0.59–26.22)	1.65 (0.21–7.54)

AILD: autoimmune liver disease; AIH: autoimmune hepatitis; IL: interleukin; IFN-γ: interferon-gamma; TNF-α: tumour necrosis factor-alpha.
compared with healthy controls group (Mann–Whitney U test);
compared with healthy controls group (Mann–Whitney U test).