Serum Cytokine Levels and Their Relation to Clinical Features in Patients with Autoimmune Liver Diseases
Table 3
Association (represented as odds ratios and 95% confidence intervals from the logistic regression analysis) between serum levels of cytokines (IL-2, IL-6, IL-8, and IL-10) and autoimmune liver diseases.
Parameter
Unadjusted model (all parameters analyzed separately)
combined model
AILD
IL-2
1.01 (0.95–1.08)
0.58 (0.32–1.03)
IL-6
3.86 (1.04–14.41)
1.56 (0.75–3.25)
IL-8
57.54 (6.15–538.08)
48.36 (3.63–643.60)
TNF-α
1.55 (1.06–2.36)
1.37 (0.93–2.00)
Age
—
0.99 (0.94–1.05)
Gender (male)
—
3.13 (0.28–35.58)
AIH
IL-2
1.03 (0.91–1.17)
0.65 (0.31–1.37)
IL-6
5.04 (1.25–20.32)
1.90 (0.70–5.13)
IL-8
30.39 (3.15–293.12)
18.54 (1.08–318.54)
TNF-α
1.41 (0.99–2.01)
1.35 (0.91–2.02)
Age
—
0.99 (0.92–1.05)
Gender (male)
—
1.59 (0.10–24.98)
Overlap syndrome
IL-2
1.02 (0.96–1.08)
0.53 (0.26–1.08)
IL-6
2.17 (0.81–5.59)
1.68 (0.53–5.30)
IL-8
22.12 (3.07–159.55)
23.85 (2.37–240.23)
TNF-α
1.35 (0.88–2.08)
1.17 (0.58–2.38)
Age
—
1.02 (0.93–1.12)
Gender (male)
—
7.47 (0.29–192.75)
The model adjusted for the levels of IL-2, IL-6, IL-8, and TNF-α, age, and male gender. AILD: autoimmune liver disease; AIH: autoimmune hepatitis; IL: interleukin; IFN-γ: interferon-gamma; TNF-α: tumour necrosis factor-alpha.
