Research Article
How to Distinguish Patients with pSS among Individuals with Dryness without Invasive Diagnostic Studies
Table 1
Values of laboratory test results, immunological markers, and severity of dryness and fatigue in patients with pSS and in the control group.
| | Study group | Number of patients/% | Number of patients/% | Minimum | Minimum | Maximum | Maximum | value | | pSS | Control | pSS | Control | pSS | Control |
| | ANA > 1 : 320 /% | 55/81% | 9/21% | 1 : 320 | 1 : 320 | 1 : 10000 | 1 : 320 | <0.000 |
| | CRP mean value | 2.38 ± 3.71 | 2.13 ± 2.84 | 0.19 | 0.00 | 24.38 | 18.30 | | | CRP > 5 mg/dl /% | 9/13% | 1/2% | | | | | 0.047 |
| | Focus-score LSB mean value | 2.22 ± 1.35 | 0.37 ± 0.93 | 0.00 | 0.00 | 4.00 | 4.00 | | | FS ≥ 1 /% | 61/90% | 10/23% | | | | | <0.001 |
| | Hemoglobin level mean value | 12.99 ± 1.78 | 13.52 ± 1.23 | 10.40 | 11.00 | 24.80 | 16.50 | | | Anaemia /% | 15/22% | 3/7% | | | | | 0.029 |
| | WBC mean value | 5.43 ± 2.09 | 5.99 ± 1.61 | 1.95 | 3.73 | 14.40 | 10.10 | | | WBC < 4 tys. /% | 19/28% | 1/2% | | | | | 0.0003 |
| | Lymphocyte mean value | 1.58 ± 1.16 | 1.79 ± 0.46 | 0.48 | 0.70 | 9.99 | 2.70 | | | Lymphopenia /% | 39/57% | 6/14% | | | | | <0.001 |
| | Oral dryness mean value | 4.76 ± 2.99 | 3.77 ± 2.93 | 0.00 | 0.00 | 10.00 | 10.00 | 0.12 | | >0 in VAS /% | 60/88% | 32/74% | | | | | 0.05 |
| | Dry eye mean value | 4.47 ± 2.69 | 4.28 ± 2.70 | 0.00 | 0.00 | 10.00 | 8.00 | 0.96 | | >0 in VAS /% | 62/91% | 36/84% | | | | | 0.18 |
| | Vaginal dryness mean value | 3.03 ± 2.73 | 2.82 ± 2.94 | 0.00 | 0.00 | 9.00 | 9.00 | 0.64 | | >0 in VAS /% | 41/62% | 11/29% | | | | | <0.000 |
| | Fatigue mean value | 5.46 ± 2.37 | 3.84 ± 2.65 | 0.00 | 0.00 | 10.00 | 8.00 | 0.04 | | >0 in VAS /% | 67/98% | 35/81% | | | | | 0.002 |
| | ESR mean value | 31.51 ± 24.77 | 16.02 ± 11.62 | 6.00 | 1.00 | 103.00 | 53.00 | 0.001 | | ESR > 20 mm/hr /% | 39/57% | 10/23% | | | | | 0.0004 |
| | RF mean value | 79.32 ± 128.67 | 12.31 ± 25.94 | 0.00 | 0.00 | 801.00 | 171.80 | | | RF > 14 IU/ml /% | 50/73% | 7/16% | | | | | <0.000 |
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: number of patients; normal value: ANA: antinuclear antibodies < 1 : 320 (EUROIMMUN Hep-20-10/liver Monkey set); CRP: C-reactive protein < 5 mg/dl; LSB: labial salivary gland biopsy; haemoglobin: 12–16 g/dl in women, 14–18 g/dl in men; WBC: white blood cells 4–10 k/ μl; lymphocytes: 1.5–3.5 k/ μl (in complete peripheral blood count); VAS: visual analogue scale (0–10 cm); ESR: erythrocyte sedimentation rate 3–15 mm/h; RF: 0–14 IU/ml. |
