Fn14 Deficiency Ameliorates Anti-dsDNA IgG-Induced Glomerular Damage in SCID Mice

<div>Infiltration of inflammatory cells decreases in glomeruli of Fn14-deficient mice. SCID mice were intraperitoneally injected with hybridoma cells producing control IgG or anti-dsDNA IgG. (a) By immunohistochemistry, CD3-positive cells were detected in glomeruli. (b) The CD3-stained sections were scored by semiquantitative systems. (c) Iba-1-positive cells were also detected by immunohistochemistry. (d) The Iba-1-stained sections were scored semiquantitatively. There were eight mice in each group. Representative images are shown. Fn14: fibroblast growth factor-inducible 14. 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Journal of Immunology Research

fig5

Figure 5

Figure 5: Fn14 Deficiency Ameliorates Anti-dsDNA IgG-Induced Glomerular Damage in SCID Mice 