Sex Differences in Correlation with Gene Expression Levels between Ifi200 Family Genes and Four Sets of Immune Disease-Relevant Genes

Figure 3

Gene network and sex difference between Ifi200 family genes and reported lupus-relevant genes. (a) Gene network between Ifi200 family genes and reported lupus-relevant genes in male mice. The 58 edges between the nodes, filtered from the 276 total edges and drawn as curves. (b) Gene network between Ifi200 family genes and reported lupus-relevant genes in female mice. The 37 edges between the nodes, filtered from the 276 total edges and drawn as curves. In (c) and (d), the numbers on the vertical bar indicate the scale of values between the expression level of Ifi202b and each gene listed at the bottom of the figure. Female and male mice are indicated with red (female) and blue (male) color. (c) Sex difference of correlation on expression levels between Ifi203 and lupus-relevant genes in spleen. Black bars indicate that Jhdm1d showed most sex difference when its expression level is correlated with that of Ifi203. (d) Sex difference of correlation of expression levels between Ifi205 and lupus-relevant genes in spleen. Black bars indicate that Jhdm1d showed the most sex difference when its expression level is correlated with that of Ifi205. (e) The expression levels of Ifi200 family genes, some important immune-related genes, and Jhdm1d in female and male mice of strain NZB/BlNJ. The numbers on the vertical bar indicate the scale of the relative expression level of each gene. Gene names are listed at the bottom of the figure. Female and male mice are indicated with red (female) and blue (male) color.

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