Distinct Profiles of CD163-Positive Macrophages in Idiopathic Interstitial Pneumonias

Figure 2

Immunohistochemical analysis of the expression of CD163 in IIPs. CD163⁺ macrophages (Brown) are observed to be scattered in normal control lungs (a). In IPF/UIP, numerous alveolar macrophages show weak or no expression of CD163 (b). Numerous CD163⁺ macrophages are observed predominantly in alveolar space of NSIP (c) and COP (d) and in interstitium too. CD163⁺ macrophages were rarely detected within fibroblastic foci in IPF/UIP and the intraluminal fibrosis in COP. Resorcin-fuchsin and hematoxylin were used as counterstains. Scale bar: (a) 100 μm and (b–d) 200 μm.

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