Research Article
Distinct Profiles of CD163-Positive Macrophages in Idiopathic Interstitial Pneumonias
Table 1
Characteristics of healthy volunteers and patients with IIPs.
| | Healthy control | UIP | NSIP | COP | | | 12 | 23 | 17 | 7 | value |
| | Age | 64.3 ± 3.1 | 65.3 ± 1.6 | 54.3 ± 2.7 | 64.0 ± 3.9 | 0.015 | | Female (%) | 6 (50.0) | 10 (43.5) | 8 (46.6) | 2 (28.6) | n.s | | Smoke (%) | 6 (50.0) | 12 (52.2) | 5 (29.4) | 4 (57.2) | n.s | | Pulmonary function tests | | | | | | | FVC (L) | 3.03 ± 0.24 | 2.48 ± 0.19 | 2.55 ± 0.30 | 2.19 ± 0.23 | n.s | | FVC (%) | 112.7 ± 3.0 | 83.3 ± 4.2 | 78.4 ± 7.2 | 68.3 ± 5.9 | n.s | | FEV/FVC (%) | 77.8 ± 2.1 | 87.6 ± 2.0 | 85.0 ± 1.41 | 81.4 ± 1.9 | n.s | | DLco (%) | 114.2 ± 7.6 | 73.7 ± 5.1 | 67.8 ± 6.9 | 63.4 ± 4.8 | n.s | | Lung specimens obtained | | | | | | | Upper lobe (%) | 6 (50.0) | 5 (21.7) | 1 (5.8) | 1 (14.3) | n.s | | Lower lobe (%) | 6 (50.0) | 7 (30.4) | 3 (17.6) | 3 (42.9) | n.s | | Both lobes (%) | 0 (0) | 11 (47.8) | 13 (76.5) | 3 (42.9) | <0.001 | | Treatments | | | | | | | Corticosteroid (%) | 0 (0) | 4 (17.4) | 13 (74.5) | 5 (71.4) | <0.001 | | Immunosuppresants (%) | 0 (0) | 2 (8.7) | 5 (29.4) | 0 (0) | n.s | | Pirfenidone (%) | 0 (0) | 2 (8.7) | 1 (5.9) | 0 (0) | n.s | | None (%) | 12 (100.0) | 16 (69.6) | 3 (17.6) | 2 (28.6) | <0.001 |
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Data are shown as mean ± SD. Brackets represent percentage. IPF/UIP: idiopathic pulmonary fibrosis/usual interstitial pneumonia; NSIP: nonspecific interstitial pneumonia; COP: cryptogenic organizing pneumonia; FVC: forced vital capacity; FEV1.0: forced expiratory volume in 1 second; DLco: diffusing capacity of the lungs for carbon monoxide; n.s: no statistical significance.
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