Anti-IL-22 Antibody Attenuates Acute Graft-versus-Host Disease via Increasing Foxp3⁺ T Cell through Modulation of CD11b⁺ Cell Function

Figure 6

IL-22Ab inhibited the pathology of aGVHD via donor CD11b⁺ cells. CD11b⁺ cells were depleted among B6 spleen cells, and the remaining spleen cells were injected into D2B6F1 mice. After 14 days, mice were sacrificed, and the donor and host splenic lymphocyte subsets, as well as the expression of Foxp3 in CD4⁺ T cells, were analyzed using flow cytometry. (a) Representative plots of donor and host cells after 14 days. (b) Absolute number of total cells. (c) Relative engraftment percentage and absolute number of donor cells. (d) Representative contour plots of CD4⁺Foxp3⁺ T cells. (e) Relative number of CD25⁺Foxp3⁺ T cells among CD4⁺ cells. Data are shown as the mean ± SEM from six independent experiments. , , and .

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