Association of Cytotoxic T Lymphocyte Antigen-4 Gene Polymorphisms with Psoriasis Vulgaris: A Case-Control Study in Turkish Population

Table 4

Genotype and allele frequencies of CTLA-4 gene polymorphisms in the early-onset subgroup and late-onset subgroup and the association of these polymorphisms with onset age of Pv.

SNP	Genotype/allele	Early onset (%)	Late onset (%)	HWE (early)	HWE (late)	Model	OR (95% CI)
rs5742909	CC	74 (0.84)	12 (0.8)	0.62	0.67	Codominant 1	1.42 (0.35–5.75)	0.76
(−318C>T)	CT	13 (0.15)	3 (0.2)			Codominant 2	0.00 (NA)
	TT	1 (0.01)	0 (0.0)			Dominant	1.32 (0.33–5.30)	0.7
						Recessive	0.00 (NA)
	C	188 (0.91)	176 (0.86)			Log-additive	1.19 (0.33–4.30)	0.8
	T	18 (0.09)	28 (0.14)			Minor allele	1.19 (0.32–4.39)	0.11
rs231775	AA	45 (0.51)	6 (0.4)	0.49	0.98	Codominant 1	1.54 (0.48–5.01)	0.04
(+49A>G)	AG	34 (0.39)	7 (0.47)			Codominant 2	1.67 (0.29–9.62)	0.72
	GG	9 (0.1)	2 (0.13)			Dominant	1.57 (0.52–4.78)	0.42
						Recessive	1.35 (0.26–6.97)	0.73
	A	124 (0.7)	19 (0.63)			Log-additive	1.35 (0.62–2.98)	0.45
	G	52 (0.3)	11 (0.37)			Minor allele	1.38 (0.61–3.10)	0.43
rs3087243	AA	24 (0.27)	1 (0.07)	0.06	0.13	Codominant 1	2.07 (0.59–7.30)	0.45
(CT60A>G)	AG	35 (0.4)	10 (0.67)			Codominant 2	0.30 (0.03–2.89)	0.08
	GG	29 (0.33)	4 (0.27)			Dominant	1.35 (0.40–4.61)	0.62
						Recessive	0.19 (0.02–1.53)	0.06
	A	93 (0.53)	18 (0.6)			Log-additive	0.77 (0.36–1.63)	0.49
	G	83 (0.47)	12 (0.4)			Minor allele	1.34 (0.61–2.94)	0.47

SNP: single-nucleotide polymorphism; HWE: Hardy-Weinberg equilibrium; OR: odds ratio; CI: confidence interval.