Association of Cytotoxic T Lymphocyte Antigen-4 Gene Polymorphisms with Psoriasis Vulgaris: A Case-Control Study in Turkish Population

Table 5

Genotype and allele frequencies of CTLA-4 gene polymorphisms in PASI < 12 and PASI ≥ 12 and the association of these polymorphisms with the severity of Pv.

SNP	Genotype/allele	PASI < 12 (%)	PASI ≥ 12 (%)	HWE (PASI < 12)	HWE (PASI ≥ 12)	Model	OR (95% CI)
rs5742909	CC	37 (0.84)	49 (0.83)	0.25	0.48	Codominant 1	1.26 (0.42–3.78)	0.39
(−318C>T)	CT	6 (0.14)	10 (0.17)			Codominant 2	0.00 (NA)
	TT	1 (0.02)	0 (0.0)			Dominant	1.08 (0.38–3.10)	0.89
						Recessive	0.00 (NA)
	C	188 (0.91)	176 (0.86)			Log-additive	0.93 (0.35–2.43)	0.88
	T	18 (0.09)	28 (0.14)			Minor allele	0.93 (0.35–2.45)	0.88
rs231775	AA	23 (0.52)	28 (0.47)	0.84	0.36	Codominant 1	1.05 (0.46–2.40)	0.04
(+49A>G)	AG	18 (0.41)	23(0.39)			Codominant 2	2.19 (0.52–9.22)	0.53
	GG	3 (0.07)	8 (0.14)			Dominant	1.21 (0.55–2.65)	0.63
						Recessive	2.14 (0.53–8.60)	0.26
	A	64 (0.73)	79 (0.67)			Log-additive	1.30 (0.72–2.34)	0.39
	G	24 (0.27)	39 (0.37)			Minor allele	1.32 (0.72–2.41)	0.37
rs3087243	AA	13 (0.3)	12 (0.2)	0.79	0.23	Codominant 1	0.50 (0.19–1.28)	0.08
(CT60A>G)	AG	35 (0.4)	24 (0.41)			Codominant 2	0.40 (0.14–1.18)	0.19
	GG	10 (0.23)	23 (0.39)			Dominant	0.46 (0.19–1.11)	0.08
						Recessive	0.61 (0.25–1.51)	0.28
	A	41 (0.47)	70 (0.59)			Log-additive	0.63 (0.37–1.07)	0.09
	G	47 (0.53)	48 (0.41)			Minor allele	1.67 (0.96–2.92)	0.07

SNP: single-nucleotide polymorphism; HWE: Hardy-Weinberg equilibrium; OR: odds ratio; CI: confidence interval.