OK-432 Acts as Adjuvant to Modulate T Helper 2 Inflammatory Responses in a Murine Model of Asthma

Figure 2

Pulmonary inflammatory responses induced by OVA challenge were diminished in mice preimmunized with OK-432 adjuvant. (a) Schematic diagram depicting protocols for immunization and challenge protocol. (b) Pulmonary function test was determined 24 hours after the last challenge. Mice were stimulated by increasing concentrations of methacholine (0, 10, 30, and 100 mg/ml), and airway resistances of different groups are shown. Cells in BAL fluid were stained by Liu’s stain, and the number and percentage of leukocyte were calculated. Total cell number (c) and absolute number (d) and percentage of eosinophils (e) in BAL are shown. Data are represented as the mean ± SEM ( per group) from three independent experiments. , , and .

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