OK-432 Acts as Adjuvant to Modulate T Helper 2 Inflammatory Responses in a Murine Model of Asthma

Figure 3

Histopathology shows less lung eosinophilia in mice preimmunized with OVA/OK-432 formula. (a) Formaldehyde-fixed, paraffin-embedded lung tissues from each group were sliced and stained with hematoxylin and eosin. One representative section at 200X is shown for each experimental group. Data are representatives of three independent experiments (). (b) Quantitative results of eosinophil infiltration (defined as inflammatory index) were analyzed by MetaMorph and expressed as percentage (mean ± SEM), compared to the OVA control mice. The mRNA levels of CCL11 (c), IL-4 (d), IL-5 (e), IL-13 (f), and IFN-γ (g) in lung tissues were determined by real-time PCR. Data are represented as the mean ± SEM ( per group) from three independent experiments. , , and .

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