IL-33 Protects Mice against DSS-Induced Chronic Colitis by Increasing Both Regulatory B Cell and Regulatory T Cell Responses as Well as Decreasing Th17 Cell Response

Figure 1

IL-33 treatment attenuates DSS-induced chronic colitis in the C57BL/6 mice. Mice were orally treated with 2% DSS in the drinking water to induce colitis as described in Materials and Methods. (a) Body weight and disease activity index were daily observed. On day 30, (b) macroscopic changes, colon length, and (c) histological score (original magnification, ×200) were analyzed. Data indicate mean ± SD of each group () obtained from a representative of three independent experiments (, ).

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