IL-33 Protects Mice against DSS-Induced Chronic Colitis by Increasing Both Regulatory B Cell and Regulatory T Cell Responses as Well as Decreasing Th17 Cell Response

Figure 4

The population of cytokine-producing T cells in the MLN of IL-33- and PBS-treated mice with DSS-induced colitis was analyzed by flow cytometry. (a) The frequencies and the absolute numbers of CD4⁺IL-17A⁺ and CD4⁺IL-17A⁺IFN-γ⁺ T cells in the MLN of IL-33- and PBS-treated mice with DSS-induced chronic colitis. (b) The absolute numbers of cytokine-producing CD4⁺IL-17A⁺ and CD4⁺IL-17A⁺IFN-γ⁺ T cells of the MLN with and without stimulation. Data indicate mean ± SD of each group () obtained from a representative of three independent experiments. Statistically significant differences are shown (, ).

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