Acute Neuroinflammatory Response in the Substantia Nigra Pars Compacta of Rats after a Local Injection of Lipopolysaccharide

<div>Levels of cytokines in the substantia nigra after LPS local injection. qPCR (a–e) and ELISA (f–j) were used to measure mRNA and protein levels, respectively, for TNF-<i>α</i>, IL-1<i>β</i>, and IL-6 (proinflammatory cytokines) and IL-4 and IL-10 (anti-inflammatory cytokines). Ut = untreated control rats. Mock = rats injected with the vehicle (2 <i>μ</i>L of endotoxin-free physiological saline solution) in the left substantia nigra. 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Repeated-measures one-way ANOVA and Newman-Keuls post hoc test for ELISA and repeated-measures two-way ANOVA and Bonferroni post hoc test for the qPCR assay.</div>

Journal of Immunology Research

fig7

Figure 7

Figure 7: Acute Neuroinflammatory Response in the Substantia Nigra Pars Compacta of Rats after a Local Injection of Lipopolysaccharide 