Acute Neuroinflammatory Response in the Substantia Nigra Pars Compacta of Rats after a Local Injection of Lipopolysaccharide

Figure 9

Apparent phagocytosis of damaged dopaminergic neurons by microglia. Representative confocal micrographs of TH and OX42 double immunofluorescence. (a) Integrated projections from x-y optical stacks. (b) Orthogonal projections from a 1 μm z-confocal optical section. The arrows show a green fluorescence dot (TH immunoreactivity) surrounded by a red fluorescence ring (OX42). The right top panel corresponds to the integrated image where the orthogonal analysis was performed.

(a)

(b)