Sirtuin1 Targeting Reverses Innate and Adaptive Immune Tolerance in Septic Mice

Figure 1

SIRT1 inhibition has no effect on frequency and number changes in total splenocyte and CD4+ T cells during sepsis-induced immunosuppression. All data presented as sham versus CLP versus CLP + EX-527. (a) Cumulative results of total splenocytes presented as total cell number. (b, c) Cumulative results from surface CD4 presented as (b) frequency of total splenocytes (%) and (c) absolute cell count. (d, e) Cumulative results from surface CD8 presented as (d) frequency of total splenocytes (%) and (e) absolute cell count. Data are representative of three independent analyses with a total of 5 mice in each group. Data are expressed as mean ± SEM. mice/group. .

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