Natural Killer Cells from Malignant Pleural Effusion Are Endowed with a Decidual-Like Proangiogenic Polarization

Figure 5

Modulation of degranulation (CD107a) and perforin secretion in NK cell subsets. Flow cytometric analysis for CD107a surface marker showed a downregulation of CD107a expression on PB-NK and PE-NK cells in terms of percentage of positive cells (a) and mean intensity of fluorescence (MFI) (b) that correlated with a significant decrease of the percentage of perforin⁺ NK cells, both in CD56^dim and CD56^bright subsets in iPE and ptPE (c, d) after exposure to target K562 cells. Representative dot plots of perforin expression in healthy donors and patients with inflammatory, primary, and metastatic tumor PE are shown, respectively (e). Data are shown as mean ± SEM of 34 samples; and ( values are shown).

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