Analysis of ROR1 Protein Expression in Mice with Reconstituted Human Immune System Components

Figure 3

Frequency of ROR1-expressing B cells maintained in huNSG mice. (a) The frequency of ROR1⁺ B cells within human CD45⁺ cells in the blood of huNSG mice was analyzed in different time points after reconstitution. Data from 3 different cohorts of huNSG mice are shown individually (R1, R2, and R3) and as composite data (three cohorts). (b) Frequency of ROR1⁺ B cells within human CD45⁺ cells in the bone marrow (left) and spleen (right) of huNSG mice at different time points. Horizontal lines represent mean and SD. (c) Correlation of the frequencies of ROR1⁺CD19⁺ cells with the frequencies of human CD19⁺ B cells, CD3⁺ T cells, and NKp46⁺ NK cells in huNSG mice. The Pearson coefficient is shown, a two-tailed statistical analysis was performed, and the value is shown.

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