OSU-T315 as an Interesting Lead Molecule for Novel B Cell-Specific Therapeutics

Figure 11

Inhibitory activity of OSU-T315 on cytokine production and proliferation of splenic WT or ILK KO B lymphocytes stimulated by LPS. Freshly isolated splenic B cells from an ILK WT (black) mouse and an ILK KO (grey) mouse underwent stimulation with LPS (5 μg/ml). The production of IL6 (a) and TNFα (b) was measured after 2 days and the proliferation (c) after 3 days. Plotted data are the means with SEM of sextuplets. The graphics show data from one representative of the two independently performed experiments.

(a)

(b)

(c)