OSU-T315 as an Interesting Lead Molecule for Novel B Cell-Specific Therapeutics

Table 1

In vitro phenotypic characterization of OSU-T315 on Namalwa.

In vitro analysis	IC50 (nM)	SEM (nM)
Flow cytometry
CD40	270	15
CD69	630	150
CD70	740	55
CD80	240	90
CD83	620	70
CD86	300	95
WST-1	4600	125

Namalwa cells were stimulated with 0.1 μM ODN2006 in the presence of different concentrations of OSU-T315 and were analyzed 24 hours later by flow cytometry. The cytotoxicity of OSU-T315 on Namalwa cells was assessed by the WST-1 assay after 48 hours of incubation of the cells with different concentrations of the compound. Data are the means with SEM of 3 independently performed experiments.