Journal of Immunology Research / 2018 / Article / Tab 1

Review Article

Mast Cell, the Neglected Member of the Tumor Microenvironment: Role in Breast Cancer

Table 1

Studies analyzing the participation of mast cells in breast cancer.

Study typeBC specimenMC detection methodPrognosis in BCAssociationRef.

D/C/ETumor tissue and blood xenotransplanted miceTryptasePositiveDecreased blood clotting and hypoxia[94]
D/CTumor tissuec-kit (CD117)PositiveGreater survival[95]
D/CTumor tissue from IDCc-kit (CD117)PositiveGreater survival[87]
D/CTumor tissueGiemsa and Alcian bluePositiveBC subtype[88]
D/CLymph nodesToluidine bluePositiveGreater survival[91]
D/CTumor tissue from IDCTryptase and chymasePositiveBC subtypes[89]
D/CSentinel lymph nodesTryptaseNegativeAngiogenesis and micrometastasis[90]
D/CTumor tissueTryptaseNegativeAngiogenesis[92]
D/CTumor tissue and sera to measure tryptase levelsTryptaseNegativeAngiogenesis[93]
D/CTumor tissue and lymph nodes from IDC patientsToluidine blueNegativeAngiogenesis[98]
D/CTumor tissue from IDCToluidine blueNegativeBC grade[99]
D/C/EBenign growths and tumor tissues
Cell line treated with tryptase
TryptaseNegativeBC grade and metastasis[104]
EMast cell-deficient BC-prone miceToluidine blueNegativeProgression, metastasis, and angiogenesis[105]
C/ETumor tissue from cimetidine treated patientsToluidine blueNoneNone[111]

BC: breast cancer; IDC: invasive ductal carcinoma; D: descriptive study; C: correlative; E: experimentally tested; positive: antitumoral role; negative: protumoral role. Studies also performed in mice.

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