Assessing the Role of DNA Methylation-Derived Neutrophil-to-Lymphocyte Ratio in Rheumatoid Arthritis

Table 2

Association between mdNLR and rheumatoid arthritis status.

Study	Variables	OR (95% CI)	value
New onset RA (GSE42861) ()
	mdNLR	2.32 (1.95–2.80)	<2×10^−16
	Age	1.00 (0.98–1.01)	0.81
	Gender
	Female	Reference	NA
	Male	0.82 (0.52–1.28)	0.38
	Smoking status
	Current	Reference	NA
	Former	0.90 (0.55–1.47)	0.67
	Occasional	0.92 (0.45–1.86)	0.81
	Never	0.68 (0.41–1.13)	0.14
Preclinical RA (ALSPAC sample during pregnancy) ()^@
	mdNLR	4.30 (1.52–21.71)	0.029
	Age	1.00 (0.79–1.25)	0.996
	Smoking status
	Current	Reference	NA
	Former	0.03 (0.00–1.50)	0.105
	Never	0.07 (0.00–0.73)	0.043
Prevalent treated RA (ALSPAC 18 years after pregnancy) ()^@
	mdNLR	0.34 (0.05–1.82)	0.23
	Age	0.97 (0.82–1.15)	0.81
	Smoking status
	Current	Reference	NA
	Former	0.19 (0.01-2.67)	0.23
	Never	0.15 (0.01–1.77)	0.15
TNFi response dataset (BRAGGSS) ()^@
	mdNLR	1.10 (0.75–1.68)	0.64
	Age	1.03 (0.98–1.09)	0.26
	Gender
	Female	Reference	NA
	Male	0.60 (0.10–3.00)	0.54
	Smoking status
	Current	Reference	NA
	Former	0.56 (0.10–3.18)	0.51
	Never	1.02 (0.19–5.69)	0.98
	DAS28	0.62 (0.28–1.25)	0.20
	Use of DMARDs	1.86 (0.31–15.15)	0.51

Model was in addition adjusted for 10 surrogate variables. ^@Model was in addition adjusted for batch.