Microbiota Composition and the Integration of Exogenous and Endogenous Signals in Reactive Nasal Inflammation

Figure 3

The effect of corticosteroid treatment on eosinophilic inflammation in CRSwNP. Hematoxylin and eosin stainings of polyp sections from two patients with CRSwNP before (a and c) and after (b and d) a short course of oral prednisone (0.4 mg/kg/day for 7 days) prior to polyp resection by functional endoscopic sinus surgery. Both patients did not have any allergies and were aspirin-intolerant. Polyp size and eosinophilic infiltration in the first patient (a and b), a 50-year-old female, were promptly reduced following prednisone administration, whereas polyp size and histology in the second patient (c and d), a 69-year-old male, remained substantially unchanged (F.A. Salzano and C. Stellato, unpublished observations).

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