High-Density Lipoprotein Reduction Differentially Modulates to Classical and Nonclassical Monocyte Subpopulations in Metabolic Syndrome Patients and in LPS-Stimulated Primary Human Monocytes In Vitro

Table 2

Correlation coefficients of monocyte subpopulations with anthropometric, metabolic, and cellular parameters in patients with metabolic syndrome and controls.

Parameters	Control						Metabolic syndrome
	CM		IM		NCM		CM		IM		NCM
	r		r		r		r		r		r
Age	0.242	0.126	0.046	0.414	−0.217	0.153	0.078	0.351	0.203	0.159	−0.028	0.446
BMI	−0.523	0.004	0.140	0.256	0.592	0.001	0.037	0.427	−0.077	0.354	0.034	0.433
WC	−0.323	0.065	0.220	0.155	0.353	0.049	0.103	0.307	0.011	0.477	−0.011	0.477
Body fat	−0.363	0.043	0.236	0.139	0.438	0.018	0.240	0.118	−0.005	0.488	−0.051	0.402
SBP	0.024	0.548	0.017	0.471	0.057	0.210	0.051	0.412	0.072	0.347	0.054	0.207
FBG	−0.237	0.132	−0.342	0.059	0.326	0.081	0.139	0.249	0.150	0.231	−0.082	0.344
Insulin	−0.012	0.476	−0.006	0.487	−0.052	0.403	−0.066	0.373	0.103	0.306	0.025	0.451
HOMA-IR	−0.042	0.421	−0.161	0.224	0.098	0.323	0.017	0.465	0.172	0.199	−0.005	0.489
Cholesterol	−0.204	0.169	0.171	0.212	−0.093	0.332	0.010	0.478	0.008	0.484	−0.175	0.196
Triglycerides	−0.111	0.306	−0.018	0.466	−0.187	0.196	−0.009	0.481	0.185	0.181	−0.154	0.226
HDL	−0.032	0.440	−0.180	0.198	0.086	0.343	0.531	0.013	0.209	0.152	−0.621	0.009
LDL	−0.214	0.156	0.249	0.120	−0.046	0.414	−0.144	0.240	−0.158	0.220	0.026	0.449
CM	—	—	0.325	0.060	−0.585	0.001	—	—	0.237	0.121	−0.727	<0.001
IM	0.319	0.064	—	—	0.084	0.695	0.237	0.121	—	—	−0.166	0.207
NCM	−0.585	0.001	0.084	0.347	—	—	−0.727	<0.001	−0.166	0.207	—	—

Coefficients (r) and values were calculated by Pearson’s correlation model. The correlation level was considered significant when . Significant associations are marked in italics. CM: classical monocytes; IM: intermediate monocytes; NCM: nonclassical monocytes; BMI: body mass index; WC: waist circumference; SBP: systolic blood pressure; FBG: fasting blood glucose; HOMA-IR: homeostatic model assessment of insulin resistance; HDL: high-density lipoprotein; LDL: low-density lipoprotein. Diagnosis of metabolic syndrome was performed according to the ATP III criteria, when three of five of the following factors were present: central obesity denoted by a waist circumference greater than 80 cm in women and 90 cm in men, hypertriglyceridemia (circulating triglyceride ), decreased serum values of HDL-cholesterol (serum in men and 50 mg/dL in women), blood pressure higher than 120/80 mmHg, and hyperglycemia (fasting blood ).