Clinical Study
Association between HLA-B Alleles and Carbamazepine-Induced Maculopapular Exanthema and Severe Cutaneous Reactions in Thai Patients
Table 1
Clinical characteristic of patients with carbamazepine-induced cutaneous adverse drug reactions and carbamazepine-tolerant controls.
| | Demographic data | Cases () | Tolerant controls () | value |
| | Gender (n/%) | 0.145 | | Male | 24/63.15 | 137/50.6 | | | Female | 14/33.84 | 134/49.4 | | | Age (mean/range) | 44/24–64 | 32/10–54 | 0.010 | | Indication (n/%) | | Epilepsy | 29/75.31 | 108/39.85 | 2.26 × 10−5 | | Neuropathic pain | 2/5.26 | 23/8.5 | 0.752 | | Trigeminal neuralgia | 5/13.2 | 62/22.88 | 0.173 | | Bipolar disorder | 1/2.6 | 10/3.7 | 1.000 | | Paroxysmal kinesigenic and nonkinesigenic dyskinesia | 1/2.6 | 7/2.6 | 1.000 | | Autism | — | 35/12.9 | 0.012 | | Schizophrenia | — | 18/6.6 | 0.143 | | Others | — | 8/3.0 | 0.602 | | Dose of carbamazepine; mg/day (mean ± SD) | 325 ± 75 | 418 ± 19 | 0.397 | | Onset of cADRs; days (mean ± SD) | 16 ± 7 | — | — | | cADRs (n/%) | | MPE | 17/45 | — | — | | SJS/TEN | 16/42 | — | — | | DRESS | 5/13 | — | — |
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cADRs: cutaneous adverse drug reactions; SJS/TEN: Stevens-Johnson syndrome/toxic epidermal necrolysis; DRESS: drug reaction with eosinophilia and systemic symptoms; MPE: maculopapular exanthema.
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