Association between HLA-B Alleles and Carbamazepine-Induced Maculopapular Exanthema and Severe Cutaneous Reactions in Thai Patients

Table 3

Association of HLA-B alleles with carbamazepine-induced MPE.

HLA-B alleles	Carbamazepine-induced MPE ()	Controls ()	Thai population ()	Carbamazepine-induced MPE cases versus tolerant controls		Carbamazepine-induced MPE cases versus Thai population
				OR (95% CI)	value	OR (95% CI)	value
B07:05	1 (5.88%)	12 (4.43%)	24 (5.11%)	1.44 (0.18–11.81)	0.533	1.234 (0.16–9.78)	0.576
B13:02	1 (5.88%)	6 (2.21%)	20 (4.26%)	2.94 (0.33–26.05)	0.334	1.50 (0.19–11.93)	0.512
B15:02	4 (23.52%)	11 (4.06%)	71 (15.11%)	7.27 (2.04–25.97)	0.002	2.30 (0.36–4.67)	0.721
B18:01	1 (5.88%)	29 (10.70%)	36 (7.66%)	0.19 (0.03–1.40)	0.098	0.80 (0.10–6.26)	1.000
B18:15	1 (5.88%)	0 (0.00%)	0 (0.00%)	18.07 (1.08–303.14)	0.108	31.33 (1.87–525.19)	0.065
B27:04	1 (5.88%)	12 (4.43%)	19 (4.04%)	1.44 (0.18–11.81)	0.533	1.58 (0.20–12.61)	0.495
B40:01	3 (17.65%)	41 (15.13%)	58 (12.34%)	1.30 (0.35–4.74)	0.720	1.64 (0.45–5.93)	0.438
B44:03	2 (11.77%)	20 (7.38%)	42 (8.94%)	1.72 (0.37–8.11)	0.369	1.46 (0.32–6.62)	0.648
B46 :01	3 (17.65%)	64 (23.62%)	122 (25.96%)	0.69 (0.19–2.49)	0.574	0.66 (0.18–2.35)	0.772
B51:01	3 (17.65%)	21 (7.75%)	40 (8.51%)	2.55 (0.69–9.60)	0.166	2.30 (0.65–8.35)	0.204
B57:01	1 (5.88%)	9 (3.32%)	11 (2.34%)	1.94 (0.23–16.34)	0.442	2.78 (0.34–22.96)	0.334
B58:01	5 (29.41%)	22 (8.12%)	57 (12.13%)	4.74 (1.53–14.66)	0.007	3.03 (1.03–8.88)	0.045

MPE: maculopapular exanthema; OR: odds ratio; 95% CI: confidence interval 95%. value less than 0.05.