Association between HLA-B Alleles and Carbamazepine-Induced Maculopapular Exanthema and Severe Cutaneous Reactions in Thai Patients

Table 4

Association of HLA-B alleles with carbamazepine-induced SJS/TEN.

HLA-B alleles	Carbamazepine-induced SJS/TEN ()	Controls ()	Thai population ()	Carbamazepine-induced SJS/TEN cases versus tolerant controls		Carbamazepine-induced SJS/TEN cases versus Thai population
				OR (95% CI)	value	OR (95% CI)	value
B07:05	2 (12.50%)	12 (4.43%)	24 (5.11%)	3.08 (0.63–12.13)	0.165	2.65 (0.57–12.35)	0.213
B13:01	1 (6.25%)	37 (13.65%)	54 (11.49%)	0.40 (0.05–3.07)	0.709	0.48 (0.06–3.70)	0.707
B15:01	1 (6.25%)	10 (3.69%)	5 (1.06%)	1.63 (0.20–13.55)	0.494	5.81 (0.64–52.67)	0.193
B15:02	12 (75.00%)	11 (4.06%)	71 (15.11%)	70.91 (19.67–255.65)	4.46 × 10^−13	18.26 (5.79–57.61)	6.9 × 10^−8
B15:21	2 (12.50%)	4 (1.48%)	2 (0.43%)	9.54 (1.61–56.57)	0.013	19.14 (2.51–146.09)	0.004
B18:01	2 (12.50%)	29 (10.70%)	36 (7.66%)	1.19 (0.26–5.51)	0.822	1.72 (0.38–7.88)	0.483
B18:15	1 (6.25%)	0 (0.00%)	0 (0.00%)	16.94 (1.01–183.39)	0.114	29.38 (1.76–490.97)	0.069
B44:03	1 (6.25%)	20 (7.38%)	42 (8.94%)	0.78 (0.10–6.22)	1.000	0.37 (0.05–2.89)	0.484
B46:01	4 (25.00%)	64 (23.62%)	122 (25.96%)	1.08 (0.34–3.46)	0.899	0.96 (0.30–3.03)	0.947
B56:04	1 (6.25%)	1 (0.37%)	12 (2.55%)	16.88 (1.01–282.35)	0.115	2.39 (0.29–19.48)	0.374
B58:01	1 (6.25%)	22 (8.12%)	57 (12.13%)	0.71 (0.09–5.59)	1.000	0.45 (0.06–3.48)	0.707

SJS/TEN: Stevens-Johnson syndrome/toxic epidermal necrolysis; OR: odds ratio; 95% CI: confidence interval 95%. value less than 0.05.