Association between HLA-B Alleles and Carbamazepine-Induced Maculopapular Exanthema and Severe Cutaneous Reactions in Thai Patients

Table 5

Association of HLA-B alleles with carbamazepine-induced DRESS.

HLA-B alleles	Carbamazepine-induced DRESS ()	Controls ()	Thai population ()	Carbamazepine-induced DRESS cases versus tolerant controls		Carbamazepine-induced DRESS cases versus Thai population
				OR (95% CI)	value	OR (95% CI)	value
B15:02	1 (20.00%)	11 (4.06%)	71 (15.11%)	5.91 (0.61–57.36)	0.126	1.41 (0.16–12.75)	0.562
B18:01	1 (20.00%)	29 (10.70%)	36 (7.66%)	2.09 (0.23–19.30)	0.440	3.01 (0.33–27.68)	0.325
B27:04	1 (20.00%)	12 (4.43%)	19 (4.04%)	5.40 (0.56–52.04)	0.216	5.93 (0.63–55.68)	0.194
B27:06	1 (20.00%)	8 (2.95%)	12 (2.55%)	8.22 (0.82–82.09)	0.154	9.54 (0.99–91.90)	0.130
B40:01	2 (40.00%)	41 (15.13%)	58 (12.34%)	3.74 (0.61–23.08)	0.174	4.74 (0.78–28.94)	0.122
B51:01	1 (20.00%)	21 (7.75%)	40 (8.51%)	2.98 (0.32–27.85)	0.339	2.69 (0.29–24.63)	0.382
B58:01	2 (40.00%)	22 (8.12%)	57 (12.13%)	7.55 (1.20–47.58)	0.032	4.83 (0.79–29.53)	0.088

DRESS: drug reaction with eosinophilia and systemic symptoms; OR: odds ratio; 95% CI: confidence interval 95%. value less than 0.05.