Cancer Immunotherapy: Priming the Host Immune Response with Live Attenuated Salmonella enterica

Table 1

Antitumoral intrinsic activity of Salmonella enterica.

Specie	Strain	Mutation	Tumor-bearing mice	Administration	Reference
Salmonella Typhimurium	S14028	pur: ilv; arg; ura; aro	Melanoma	Intraperitoneally	[14]
Salmonella Typhimurium	SL7207; SL1344	aroA, hisG46; cheY; fliGHI; invG; phoP; sseD; ssrB; purA	Colon cancer	Intravenously, intraperitoneally	[30]
Salmonella Typhimurium	SL3235	aroA	Plasmocytoma	Intraperitoneally	[43]
Salmonella Typhimurium	VNP20009	purI, msbB	Melanoma	Orally, intraperitoneally	[44]
Salmonella Typhimurium	Wild-type LT2	ΔppGpp hisD2550, rpoS, aroA, rfaH, thyA	Prostate cancer	Intraperitoneally	[46]
Salmonella Typhimurium	14028 auxotrophy A1 and A1-R	Leu, Arg	Prostate cancer	Intratumorally, intravenously	[50, 51]
			Breast cancer	Intravenously	[49]
			Breast cancer bone metastasis	Intravenously	[53]
			Bone tumor and lung metastasis of osteosarcoma	Intravenously	[54]
			Pancreatic cancer	Intraperitoneally, Intratumorally	[55, 56]
			Spinal cord glioma	Intravenously	[57]
Salmonella Typhimurium	LVR01	aroC	B-cell lymphoma	Intratumorally	[48]
Salmonella Typhi	CVD915	guaBA	T-cell lymphoma	Intratumorally, subcutaneously	[47]
PDOX Models
Salmonella Typhimurium	A1-R	Leu, Arg	Osteosarcoma metastasis	Intravenously	[60]
			Osteosarcoma	Intra-arterial	[61]
				Intratumorally	[62]
			Melanoma	Orally	[64]
				Intravenously	[65–67]
			Follicular dendritic cell sarcoma	Intraperitoneally	[68]
			Soft tissue sarcoma	Intratumorally	[69]
				Intravenously	[70]
Clinical Trial Phase I
Salmonella Typhimurium	VNP20009	purI, msbB	Metastasic melanoma	Intravenously	[71]