An Increased Frequency in HLA Class I Alleles and Haplotypes Suggests Genetic Susceptibility to Influenza A (H1N1) 2009 Pandemic: A Case-Control Study
Table 2
HLA-A allele frequencies in patients with influenza A/H1N1 infection (INF-P) and asymptomatic healthy contacts (INF-C).
HLA-A
INF-P
INF-C
pC
OR
95% CI
AF
(%)
AF
(%)
A02:01:01
68
0.2464
24.638
120
0.2667
26.667
A68:01:02
32
0.1159
11.594
41
0.0911
9.111
A24:02:01
22
0.0797
7.971
84
0.1867
18.667
0.3774
0.2298–0.6197
A03:01:01
21
0.0761
7.609
27
0.0600
6.000
A31:01:02
20
0.0725
7.246
22
0.0489
4.889
A01:01:01
18
0.0652
6.522
23
0.0511
5.111
A02:06:01
17
0.0616
6.159
19
0.0422
4.222
A29:02:01
10
0.0362
3.623
10
0.0222
2.222
A26:01:01
8
0.0290
2.899
8
0.0178
1.778
A32:01:01
8
0.0290
2.899
7
0.0156
1.556
A30:02:01
7
0.0254
2.536
10
0.0222
2.222
A23:01:01
6
0.0217
2.174
14
0.0311
3.111
A26:01:02
5
0.0181
1.812
4
0.0089
0.889
A68:01:01
5
0.0181
1.812
0
Und
Und-Und
A01:03
3
0.0109
1.087
1
0.0022
0.222
A11:24:02
3
0.0109
1.087
0
A33:01:02
3
0.0109
1.087
11
0.0244
2.444
A66:02
3
0.0109
1.087
0
A68:02:01
3
0.0109
1.087
1
0.0022
0.222
A25:01:01
2
0.0072
0.725
3
0.0067
0.667
A33:01:01
2
0.0072
0.725
0
A02:04
1
0.0036
0.362
0
A02:05:01
1
0.0036
0.362
0
A11:01:01
1
0.0036
0.362
13
0.0289
2.889
0.1222
0.0159–0.9397
A23:01:02
1
0.0036
0.362
0
A23:02
1
0.0036
0.362
0
A24:02:06
1
0.0036
0.362
0
A30:01:01
1
0.0036
0.362
1
0.0022
0.222
A32:02:01
1
0.0036
0.362
1
0.0022
0.222
A68:03:01
1
0.0036
0.362
1
0.0022
0.222
A74:02:01
1
0.0036
0.362
0
A01:01:02
0
2
0.0044
0.444
A02:01:02
0
1
0.0022
0.222
A02:02:01
0
3
0.0067
0.667
A02:03:01
0
1
0.0022
0.222
A11:01:02
0
1
0.0022
0.222
A11:04
0
1
0.0022
0.222
A26:02:01
0
1
0.0022
0.222
A31:02
0
4
0.0089
0.889
A31:14N
0
1
0.0022
0.222
A36:01
0
4
0.0089
0.889
A66:01:01
0
3
0.0067
0.667
A68:01:03
0
1
0.002
0.222
A68:03:02
0
1
0.002
0.222
A68:05
0
1
0.002
0.222
A69:01
0
1
0.002
0.222
A74:01
0
2
0.004
0.444
A80:01
0
1
0.002
0.222
INF-P: influenza patients; INF-C: influenza contacts; HLA: human leukocyte antigen; AF: allele frequency; : number of subjects; OR: odds ratio; CI: confidence interval; pC: value after Bonferroni correction; Und: undefined; only showing value < 0.05, which is considered significant.
