An Increased Frequency in HLA Class I Alleles and Haplotypes Suggests Genetic Susceptibility to Influenza A (H1N1) 2009 Pandemic: A Case-Control Study
Table 4
HLA-C allele frequencies in patients with influenza A/H1N1 infection (INF-P) and asymptomatic healthy contacts (INF-C).
Allele
INF-P
INF-C
pC
OR
95% CI
AF
(%)
AF
(%)
C07:02:01
60
0.2174
21.739
59
0.1311
13.111
1.8409
1.2390–2.7351
C04:01:01
50
0.1812
18.116
75
0.1667
16.667
C01:02:01
22
0.0797
7.971
31
0.0689
6.889
C08:01:01
22
0.0797
7.971
26
0.0578
5.778
C07:01:01
14
0.0507
5.073
42
0.0933
9.333
0.5191
0.2780–0.9692
C03:04:01
12
0.0435
4.348
48
0.1067
10.667
0.3807
0.1985–0.7302
C03:02:01
11
0.0399
3.986
5
0.0111
1.111
3.6943
1.2697–10.7492
C08:02:01
11
0.0399
3.986
15
0.0333
3.333
C16:01:01
11
0.0399
3.986
17
0.0378
3.778
C06:02:01
10
0.0362
3.623
14
0.0311
3.111
C05:01:01
8
0.0290
2.899
18
0.0400
4.000
C12:03:01
8
0.0290
2.899
22
0.0489
4.889
C02:02:02
6
0.0217
2.174
0
Und
Und-Und
C08:01:02
5
0.0181
1.812
0
Und
Und-Und
C15:02:01
5
0.0181
1.812
21
0.0467
4.667
C03:03:01
4
0.0145
1.449
24
0.0533
5.333
0.261
0.0896–0.7605
C03:03:02
3
0.0109
1.087
0
C03:06
3
0.0109
1.087
5
0.0111
1.111
C14:02:01
3
0.0109
1.087
4
0.0089
0.889
C03:02:02
2
0.0072
0.725
0
C02:02:01
1
0.0036
0.362
10
0.0222
2.222
C03:07
1
0.0036
0.362
0
C05:01:02
1
0.0036
0.362
0
C07:04:01
1
0.0036
0.362
6
0.0133
1.333
C17:01:01
1
0.0036
0.362
6
0.0133
1.333
C18:01
1
0.0036
0.362
0
C03:05:01
0
1
0.0022
0.222
C07:01:03
0
1
0.0022
0.222
INF-P: influenza patients; INF-C: influenza contacts; HLA: human leukocyte antigen; AF: allele frequency; : number of subjects; OR: odds ratio; CI: confidence interval; pC: value after Bonferroni correction; only showing value < 0.05, which is considered significant.
