Suppression of Proinflammatory Cytokines and Mediators in LPS-Induced RAW 264.7 Macrophages by Stem Extract of Alternanthera sessilis via the Inhibition of the NF-κB Pathway

Table 1

Total compounds identified in the crude extract of the stem part of A. sessilis using LC-MS analysis in a negative mode with its molecular mass, fragmentations, and reported biological activities.

Compounds	MW	Reported biological activities	Citations
2-O-rhamnosylvitexin	577.04	Antihyperalgesic	[15–18]
		Anti-inflammatory
		Antinociceptive
		Prothrombolytic
		Antidiabetic
Apigenin-6,8-di-C-β-D-glucopyranoside isomer	594.05	Antioxidant	[19–22]
		Anti-inflammatory
		Antinociceptive
		Anticancer Antitumor
		Hepatoprotective
		Antidiabetes
		Antiviral
		Antibacterial Antifungal
		Diabetic wound healing
Kaempferol monosulfate	364.98	Antioxidant	[19, 20, 23, 24]
		Anti-inflammatory
		Antinociceptive
		Wound healing
		Antibacterial
p-Hydroxybenzoic acid	137.02	Antioxidant	[25–28]
		Wound healing
		Analgesic
		Anti-inflammatory
		Neuroprotective
		Antibacterial
		Antifungal
		Demelanizing agent
p-Hydroxycinnamoyl moiety	164.08	Antibacterial	[28]
		Antifungal
		Demelanizing agent
Protocatechuic acid	153.02	Antioxidant	[19, 27]
		Anti-inflammatory
		Neuroprotective
Gibberellin	330.89	Antiulcer	[29, 30]
		Wound healing
		Anti-inflammatory
Daidzein	253.16	Anti-inflammatory	[31, 32]
		Antilipogenesis
Benzophenone-4	307.09	Endocrine-disrupting activity	[33]

MW: molecular weight.