Immune Response and Partial Protection against Heterologous Foot-and-Mouth Disease Virus Induced by Dendrimer Peptides in Cattle

Figure 3

Profiles of the FMDV-ASC detected in B₂T- and B₄T-vaccinated cattle after FMDV challenge. (a) Mononuclear cells were purified from mandibular lymph nodes (ML), medial retropharyngeal lymph nodes (MRL), and tracheobronchial lymph nodes (TBL) and characterized by the FMDV-ASC ELISPOT assay, using monoclonal (IgG1 and IgG2) or polyclonal (IgM and IgA) antibodies against bovine immunoglobulin isotypes as probes. (b) Total FMDV-ASC in ML, MRL, or TBL. Results are expressed as the mean number of FMDV-specific ASC per 1 × 10⁶ extracted cells. Each bar represents the mean value of 3 replicates ± SD. PPG: protected against podal generalization; PP: partial protected; NP: non-protected.

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