Research Article

Poly-L-Arginine Induces Apoptosis of NCI-H292 Cells via ERK1/2 Signaling Pathway

Figure 6

Expression of Bax, Bcl-2, caspase-3, and p-ERK/ERK in NCI-H292 cells treated with PLA and PD98059. (a) Protein expression bands were detected by Western blot. (b) The bar chart of Bcl-2/Bax. (c) The bar chart of caspase-3/β-actin. (d) The bar chart of p-ERK/ERK. Compared with PLA group, PD98059 significantly inhibited the activation of ERK1/2 and also blocked the regulatory effect of PLA on Bcl-2/Bax and cleaved caspase-3. . Compared with the control group, , , .
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