Defensive Driving: Directing HIV-1 Vaccine-Induced Humoral Immunity to the Mucosa with Chemokine Adjuvants

Figure 1

Mucosa-associated lymphoid tissues. MALT provides protection from pathogenic incursion and promotes the development of tolerance to commensal microbes. The lymphoid tissues in these sites sample the antigen directly from the environment to initiate immune exclusion or immune tolerance, and these responses are propagated in associated draining lymph nodes.