Review Article
Description of CD8+ Regulatory T Lymphocytes and Their Specific Intervention in Graft-versus-Host and Infectious Diseases, Autoimmunity, and Cancer
Table 1
Phenotypes of CD8+ Treg lymphocyte populations and their role in different pathologies.
| Pathology | Agent/condition | Phenotype of CD8+ regulatory T lymphocytes | Exert suppressive action | Model | References |
| Infection | Mycobacteria | CD25+FoxP3+CD39+ | Inhibit Th1 lymphocyte proliferation | Human | [93, 94] | | HIV | CD28−CD127loCD39+ | Inhibit mononuclear cell proliferation | Human | [97] | | Epstein-Barr virus | FoxP3+ | Inhibit CD4+ T lymphocyte proliferation and produce IL-10 | Human | [98] | Autoimmune disease | EAE | CD28− | Reduce amount of IFN-γ produced by CD4+ T lymphocytes | Mouse | [101] | | EAE | CD122+ | Inhibit characteristic IL-7 production of inflammatory process during EAE; inhibit CD4+ T lymphocyte proliferation | Mouse | [102] | | Multiple sclerosis | CD8+CD28−CD39+CD127− | Inhibit proliferation | | [103, 104] | | SLE | FoxP3+ | Regulate by TGF-β | Human | [70] | | SLE | CD25+FoxP3+ | Suppress production of autoantibodies | Human | [105] | | Primary biliary cirrhosis | CD28−CD39+CD127− | Suppress proliferation | Human | [106] | Cancer | Colorectal cancer | CD25+FoxP3+ | Inhibit CD4+CD25− T lymphocyte and Th1 cytokine production | Human | [110] | | Prostate cancer | CD25+FoxP3+ | Inhibit naïve T lymphocyte proliferation | Human | [111] | | Inoculation with tumor cell lines | CD39+Tim-3+PD-1+LAG-3+ | Exert cytotoxic activity | Mouse | [112] | GVHD | Allogeneic cells | LAG-3+FoxP3+CTLA-4+ | Suppress allogeneic response via CTLA-4 | Human | [39] | | Allogeneic cells | CD25+CTLA-4+FoxP3+ | Inhibit cell proliferation and release of cytokines as IL-1α, IL-17a, IFN-γ, and TNF-α | Human | [115] | | Allogeneic cells | CD28− | Inhibit CD4+ T lymphocyte proliferation | Human | [10] | | Allogeneic cells | CD25+FoxP3+ | Inhibit allogeneic response | Human | [123] | | Allogeneic cells | FoxP3+ | Inhibit CD4+ and CD8+ T lymphocyte proliferation and CD40, CD80, and CD86 expression in CD | Mouse | [125, 126] |
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GVHD: graft-versus-host disease; HIV: human immunodeficiency virus; EAE: experimental autoimmune encephalomyelitis.
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