March1 E3 Ubiquitin Ligase Modulates Features of Allergic Asthma in an Ovalbumin-Induced Mouse Model of Lung Inflammation

Figure 5

March1 deficiency leads to less antibody production against OVA in the ovalbumin-allergic model. Total IgE (a), OVA-specific IgE (b), and OVA-specific IgG₁ (c) were measured in the serum of WT and March1^−/− mice. , , , (trend). Data are pooled from 4 independent experiments and presented as mean with SEM (a, b); –7. In (c) (IgG1), data are pooled from 7 independent experiments and presented as median with interquartile values; –14.

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