March1 E3 Ubiquitin Ligase Modulates Features of Allergic Asthma in an Ovalbumin-Induced Mouse Model of Lung Inflammation

Figure 6

March1deficiency is associated with downregulation of IL-10 production. Splenocytes were isolated and cultured for 3 days with 1 mg/mL OVA. Supernatants were collected and assayed for IFN-γ (a), IL-5 (b), and IL-10 (c). and denote statistically significant. (trend). Data are pooled from 3 independent experiments and presented as mean with SEM; –8/group.

(a)

(b)

(c)