The Influence of Genetic Variations in the CD86 Gene on the Outcome after Allogeneic Hematopoietic Stem Cell Transplantation

Table 3

The distribution of genotypes in groups of patients with and without aGvHD in relation to CD86 gene SNPs: rs1129055, rs9831894, and rs2715267 in recipients (a) and CD86 rs1129055 in donors (b).

(a)

Recipients		aGvHD present		aGvHD absent		OR	95% CI	aGvHD present versus aGvHD absent
		N	%	N	%
rs1129055	GG	77	50.3	76	59.4	1	—	χ^2df=2 = 2.839
	AG	62	40.5	45	35.2	1.36	0.83–2.23
	AA	14	9.2	7	5.5	1.91	0.75–4.87
	Σ	153	100%	128	100%	—
	Hardy-Weinberg equilibrium
	rs9831894	AA	57	39.6	47	36.2	1		—	χ^2df=2 = 0.838
AC		63	43.8	64	49.2	0.81	0.48–1.36
CC		24	16.7	19	14.6	1.04	0.51–2.11
Σ		144	100%	130	100%	—
Hardy-Weinberg equilibrium
rs2715267	TT	69	44.8	52	40	1	—	χ^2df=2 = 1.378
	GT	64	41.6	63	48.5	0.77	0.47–1.26
	GG	21	13.6	15	11.5	1.05	0.50–2.21
	Σ	154	100%	130	100%	—
	Hardy-Weinberg equilibrium

(b)

Donors		aGvHD present		aGvHD absent		OR	95% CI	aGvHD present versus aGvHD absent
		N	%	N	%
rs1129055	GG	80	54.8	54	47.8	1	—; —	χ^2df=2 = 1.839
	AG	55	37.7	46	40.7	0.81	0.48–1.36
	AA	11	7.5	13	11.5	0.58	0.24–1.36
	Σ	146	100%	113	100%	—
	Hardy-Weinberg equilibrium

χ²_df≈10 = 8.521, . ^arefenence.