Proteomic Identification of Heat Shock-Induced Danger Signals in a Melanoma Cell Lysate Used in Dendritic Cell-Based Cancer Immunotherapy

Figure 2

Quantitative proteomic comparison of TRIMEL lysates with (HS) and without (no-HS) heat shock conditioning. (a) Principal components analysis (PCA). (b) Volcano plot representation of moderated t-test analysis. Each point represents one protein plotted by log2 fold change (FC, average of four samples) versus minus logarithm of the q-value (Bemjamini-Hochberg corrected value). The horizontal bar represents a -value cutoff of 0.01. Red dots indicate the proteins selected for further analysis.

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