Proteomic Identification of Heat Shock-Induced Danger Signals in a Melanoma Cell Lysate Used in Dendritic Cell-Based Cancer Immunotherapy

Table 1

Currently known functions of selected gene-proteins upregulated by HS. The protein lists was previously filtered by or abs (log2(FC)) > 1.

Gene	ID (NCBI)	Full name (NCBI)	Function (gene ontology)	Reference
CELF1	10658	CUGBP Elav-like family member 1	(i) BRE; RNA; mRNA; pre-mRNA; protein and translation repressor activity, nucleic acid binding	[43–48]
CPSF3	51692	Cleavage and polyadenylation specific factor 3	(i) Protein binding	[49]
FAM195B	348262	MAPK regulated corepressor interacting protein 1	(i) Protein binding	[50, 51]
GPNMB	10457	Glycoprotein NMB	(i) Chemoattractant and receptor ligand activity	[52–54]
			(ii) Heparin; protein and syndecan binding
HNRNPA3	220988	Heterogeneous nuclear ribonucleoprotein A3	(i) RNA and protein binding	[44, 45, 55]
HNRNPL	3191	Heterogeneous nuclear ribonucleoprotein L	(i) RNA; pre-mRNA; protein and transcription regulatory region DNA binding	[44, 45, 56–58]
HP	3240	Haptoglobin	(i) Hemoglobin and protein binding	[59, 60]
MYO9B	4650	Myosin IXB	(i) ATPase; GTPase activator; microfilament motor and NOT protein homodimerization activity	[61–65]
			(ii) ADP; ATP; Rho GTPase; Roundabout; actin; calmodulin and protein binding
PIR	8544	Pirin	(i) Quercetin 2,3-dioxygenase and transcription cofactor activity	[66–69]
			(ii) Metal ion and protein binding
PPAP2C	8612	Phospholipid phosphatase 2	(i) Phosphoprotein phosphatase activity	[70, 71]
			(ii) Protein binding
PRCP	5547	Prolylcarboxypeptidase	(i) Protein binding	[72]
PRKD3	23683	Protein kinase D3	(i) Kinase activity	[73, 74]
			(ii) Protein binding
PTPN12	5782	Protein tyrosine phosphatase, nonreceptor type 12	(i) Nonmembrane spanning protein tyrosine phosphatase; phosphoprotein phosphatase and protein tyrosine phosphatase activity	[75–80]
			(ii) SH3 domain and protein binding
TOM1L2	146691	Target of myb1 like 2 membrane trafficking protein	(i) Clathrin; protein and protein kinase binding	[81, 82]
U2SURP	23350	U2 snRNP associated SURP motif-containing protein	(i) RNA and protein binding	[45, 83]
UTRN	7402	Utrophin	(i) Actin; integrin; protein; protein kinase and vinculin binding	[84, 85]
ZNF638	27332	Zinc finger protein 638	(i) RNA and double-stranded DNA binding	[45, 86]

ID, identification number; NCBI, National Center for Biotechnology Information.