|
Cells | miR(s) | Target(s) | Function(s) | Ref |
|
DCs | miR-126 | Tsc-1 | Negative regulation of mTOR-miR-126-VEGFR2-axis | [178] |
miR-155 | Ship1, KPC1 | Intervenes in CD40 expression | [179] |
miR-146a | STAT1, IRF5, IRAK1, TRAF6 | Negative regulator of type I IFN pathway | [123] |
Let-7c | Blimp1 | Regulates SOCS1 and IL-6 | [139] |
|
B cells | miR-30a | Lyn | Contributes to B cell proliferation and the production of IgG antibodies | [167] |
miR-155 | Pu.1 | Decreases the level of TNF alpha production | [110] |
miR-181b | AID | Less CSR in activated B cells | [173] |
miR-150 | c-Myb | Involved in lymphocyte development and response | [180] |
miR-34a | Foxp1 | Involved in the regulation of B cell development | [181] |
miR-125b | Blimp-1, Irf4 | Contributes to B lymphocyte diversification in GC | [182] |
miR-93 | AID | Less class switch recombination in activated B cells | [173] |
miR-21 | PDCD4 | Decreased the Fas receptor-expressing B cells | [166] |
miR-1246 | EBF1 | Increase of miR-1246 expression results in less responsiveness of B cells | [170] |
|
T Cell | miR-126 | DNMT1 | T and B cell hyperactivity, regulates DNA methylation in CD4+ T cells | [140] |
miR-29b | DNMT1, Sp1 | More CD11a and CD70, unusually high global DNA hypomethylation in T cells | [143] |
miR-148a | DNMT1 | More LFA1 and CD70, increase DNA hypomethylation in T cells | [141] |
miR-21 | RASGRP1 | Activated T cell and enhanced proliferation | [141] |
miR-142-3p | CD84, IL-10 | Increased T cell activity and higher IgG production | [145] |
miR-142-5p | SAP | Increased T cell activity and higher IgG production | [145] |
miR-31 | RhoA | More production of IL-12 by changing NF-AT expression | [148] |
miR-125a | KLF13 (RFLAT-1) | Negative regulator of the feedback loop of KLF13 and RANTES production in the activated T cell pathway | [149] |
miR-224 | AIP5 | Speeds activation-induced cell death in T cells | [93] |
miR-155 | CD62L | Important for Treg cell development and function | [100] |
miR-873 | Foxo1 | Eases differentiation of CD4+ T cells into Th17 lineage | [152] |
miR-410 | IL-6 | Lower IL-6 expression, less fibrosis | [157] |
miR-125a | STAT3, IL-13, IFNg | Steadies the commitment and immunoregulatory capacity of Treg cells | [160] |
miR-181a | SHP-2, PTPN22, DUSP5, DUSP6 | Functions as an intrinsic antigen sensitivity “rheostat” throughout T cell development | [183] |
|