Research Article

Gene Expression Profiling in Behcet’s Disease Indicates an Autoimmune Component in the Pathogenesis of the Disease and Opens New Avenues for Targeted Therapy

Table 2

Annotated genes differentially expressed in BD PBC versus healthy controls grouped according to their function.

Probe set IDGene titleGene symbolFC valueRepresentative public ID

Adaptive immune response
T cell response
 204794_atDual specificity phosphatase 2DUSP22.120.001NM_004418
 216248_s_atNuclear receptor subfamily 4, group A, member 2NR4A25.540.012NM_006186
 211861_x_atCD28 moleculeCD282.000.014AF222343
 203547_atCD4 moleculeCD42.020.016BT019811
 217394_atT cell receptor alpha variable 13-1TRAV13-12.530.001AE000521
 210439_atInducible T cell costimulatorICOS2.260.006AB023135
 221331_x_atCytotoxic T-lymphocyte-associated protein 4CTLA42.130.003NM_005214
 211085_s_atSerine/threonine kinase 4STK4/MST12.140.005Z25430
 205456_atCD3e molecule, epsilon (CD3-TCR complex)CD3E2.110.004NM_000733
 208602_x_atCD6 moleculeCD62.47<0.001NM_006725
 211302_s_atPhosphodiesterase 4B, cAMP specificPDE4B3.170.004L20966
 218880_atFOS-like antigen 2FOSL2/FRA23.170.005NM_005253
 206360_s_atSuppressor of cytokine signaling 3SOCS32.010.001NM_003955
 212079_s_atLysine- (K-) specific methyltransferase 2AKMT2A/MLL12.570.004NM_001197104
 209722_s_atSerpin peptidase inhibitor, clade B (ovalbumin), member 9SERPINB92.030.001NM_004155
B cell response
 201694_s_atEarly growth response 1EGR13.860.002NM_001964
 207655_s_atB cell linkerBLNK−2.10<0.001NM_013314
 215925_s_atCD72 moleculeCD72−2.090.015NM_001782
 220330_s_atSAM domain, SH3 domain, and nuclear localization signals 1SAMSN12.030.006NM_022136
 204440_atCD83 moleculeCD833.47NM_004233
 221239_s_atFc receptor-like 2FCRL2−2.360.001NM_030764
 213810_s_atAkirin 2AKIRIN23.12<0.001NM_018064
T/B cell response
 216901_s_atIKAROS family zinc finger 1 (Ikaros)IKZF1/IKAROS6.08<0.001NM_006060
 221092_atIKAROS family zinc finger 3 (Aiolos)IKZF3/AIOLOS3.110.006NM_012481
 212249_atPhosphoinositide-3-kinase, regulatory subunit 1 (alpha)PIK3R13.19<0.001JX133164
Innate immune response
201278_atDab, mitogen-responsive phosphoprotein, homolog 2DAB2−2.170.006NM_032552
205033_s_atDefensin, alpha 1DEFA13.800.007NM_004084
205468_s_atInterferon regulatory factor 5IRF52.01<0.001EF064718
M97935_5_atSignal transducer and activator of transcription 1, 91 kDaSTAT12.260.001GU211347
217199_s_atSignal transducer and activator of transcription 2, 113 kDaSTAT22.020.002S81491
217502_atInterferon-induced protein with Tetratricopeptide repeats 2IFIT22.00<0.001NM_001547
201211_s_atDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linkedDDX3X2.25<0.001NM_001356
211307_s_atFc fragment of IgA, receptor forFCAR/CD895.040.004U43677
212105_s_atDEAH (Asp-Glu-Ala-His) box helicase 9DHX93.82<0.001NM_001357
200613_atAdaptor-related protein complex 2, mu 1 subunitAP2M12.17<0.001NM_004068
NK cell response
 215339_atNatural killer-tumor recognition sequenceNKTR2.150.001NM_005385
 211242_x_atKiller cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4KIR2DL42.000.004AF276292
 216552_x_atKiller cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4KIR2DS42.080.002NM_001281972
 209722_s_atSerpin peptidase inhibitor, clade B (ovalbumin), member 9SERPINB92.030.001NM_004155
Adaptive/innate immune response
204863_s_atInterleukin 6 signal transducer (gp130, oncostatin M receptor)IL6ST4.440.005AB102799
211192_s_atCD84 moleculeCD842.320.002AF054818
213810_s_atAkirin 2AKIRIN23.120.001AW007137
209722_s_atSerpin peptidase inhibitor, clade B (ovalbumin), member 9SERPINB92.030.001NM_004155
221491_x_atMajor histocompatibility complex, class II, DR beta 1HLA-DRB12.19<0.001U65585
213494_s_atYY1 transcription factorYY12.000.006NM_003403
Toll-like receptors signaling
205067_atInterleukin 1, betaIL-1B6.320.001NM_000576
206676_atCarcinoembryonic antigen-related cell adhesion molecule 8CEACAM85.070.003M33326
204924_atToll-like receptor 2TLR22.000.015NM_003264
221060_s_atToll-like receptor 4TLR42.100.001NM_003266
211027_s_atInhibitor of kappa light polypeptide gene enhancer in B cells, kinase betaIKBKB/IKKb2.33<0.001AY663108
213281_atJun protooncogeneJUN/AP14.510.011NM_002228
206035_atV-rel reticuloendotheliosis viral oncogene homologREL/c-REL2.560.005NM_002908
217738_atNicotinamide phosphoribosyltransferaseNAMPT2.640.008NM_005746
216450_x_atHeat shock protein 90 kDa beta (Grp94), member 1HSP90B1/GP963.24<0.001NM_003299
214370_atS100 calcium binding protein A8S100A83.85<0.001NM_002964
211016_x_atHeat shock 70 kDa protein 4HSPA42.25<0.001NM_002154
211622_s_atADP-ribosylation factor 3ARF32.12<0.001M33384
Type I interferon signaling
205468_s_atInterferon regulatory factor 5IRF52.01<0.001EF064718
M97935_5_atSignal transducer and activator of transcription 1, 91 kDaSTAT12.260.001GU211347
217199_s_atSignal transducer and activator of transcription 2, 113 kDaSTAT22.020.002S81491
216598_s_atChemokine (C-C motif) ligand 2CCL22.000.002S69738
210001_s_atSuppressor of cytokine signaling 1SOCS12.160.012AB005043
207433_atInterleukin 10IL-102.16<0.001NM_000572
210512_s_atVascular endothelial growth factor AVEGFA2.010.003AF022375
217502_atInterferon-induced protein with tetratricopeptide repeats 2IFIT22.00<0.001NM_001547
201211_s_atDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linkedDDX3X2.25<0.001NM_001356
JAK/STAT signaling
M97935_5_atSignal transducer and activator of transcription 1, 91 kdaSTAT12.260.001GU211347
217199_s_atSignal transducer and activator of transcription 2, 113 kdaSTAT22.020.002S81491
204863_s_atInterleukin 6 signal transducer (gp130, oncostatin M receptor)IL6ST4.440.005AB102799
207433_atInterleukin 10IL-102.16<0.001NM_000572
217489_s_atInterleukin 6 receptorIL6R2.030.011S72848
212249_atPhosphoinositide-3-kinase, regulatory subunit 1 (alpha)PIK3R13.19<0.001JX133164
210001_s_atSuppressor of cytokine signaling 1SOCS12.160.012AB005043
206360_s_atSuppressor of cytokine signaling 3SOCS32.010.001NM_003955
Inflammatory response
207113_s_atTumor necrosis factorTNF2.000.008NM_000594
211506_s_atInterleukin 8IL-810.440.013AF043337
207433_atInterleukin 10IL-102.16<0.001NM_000572
205067_atInterleukin 1, betaIL-1B6.320.001NM_000576
217489_s_atInterleukin 6 receptorIL6R2.030.011S72848
209774_x_atChemokine (C-X-C motif) ligand 2CXCL25.750.007M57731
201939_atPolo-like kinase 2PLK26.200.012NM_006622
204470_atChemokine (C-X-C motif) ligand 1CXCL14.640.003NM_001511
207850_atChemokine (C-X-C motif) ligand 3CXCL33.530.015NM_002090
210118_s_atInterleukin 1, alphaIL-1A3.930.001M15329
203751_x_atJun D protooncogeneJUND3.390.008NM_005354
216598_s_atChemokine (C-C motif) ligand 2CCL22.000.002S69738
205476_atChemokine (C-C motif) ligand 20CCL202.230.011NM_004591
205114_s_atChemokine (C-C motif) ligand 3CCL32.210.007NM_002983
210001_s_atSuppressor of cytokine signaling 1SOCS12.160.012AB005043
212190_atSerpin peptidase inhibitor, clade e, member 2SERPINE2−2.140.003NM_006216
211919_s_atChemokine (C-X-C motif) receptor 4CXCR42.060.008AF348491
205099_s_atChemokine (C-C motif) receptor 1CCR12.140.002NM_001295
207075_atNLR family, pyrin domain containing 3NLRP32.150.011NM_004895
203591_s_atColony-stimulating factor 3 receptorCSF3R1.890.012NM_000760
215485_s_atIntercellular adhesion molecule 1ICAM12.040.015NM_000201
209701_atEndoplasmic reticulum aminopeptidase 1ERAP12.44<0.001NM_016442
216243_s_atInterleukin 1 receptor antagonistIL-1RN2.260.008NM_173842
202643_s_atTumor necrosis factor, alpha-induced protein 3TNFAIP32.150.012NM_001270508
201044_x_atDual specificity phosphatase 1DUSP14.710.013NM_004417
210004_atOxidized low-density lipoprotein (lectin-like) receptor 1OLR1/LOX14.130.002AF035776
214370_atS100 calcium binding protein A8S100A83.85<0.001AW238654
213281_atJun protooncogeneJUN/AP14.510.011NM_002228
216450_x_atHeat shock protein 90 kDa beta (Grp94), member 1HSP90B1/GP963.24<0.001NM_003299
Vascular damage
Blood coagulation
 204614_atSerpin peptidase inhibitor, clade B (ovalbumin), member 2SERPINB23.960.013NM_002575
 202833_s_atSerpin peptidase inhibitor, clade A, member 1SERPINA12.25<0.001NM_000295
 207808_s_atProtein S alphaPROS1−2.160.002NM_000313
 201110_s_atThrombospondin 1THBS15.080.001NM_003246
 204713_s_atCoagulation factor V (proaccelerin, labile factor)F52.530.001NM_000130
 203294_s_atLectin, mannose binding, 1LMAN12.50<0.001U09716
 213258_atTissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)TFPI−2.530.001BF511231
 203650_atProtein C receptor, endothelialPROCR−2.670.001NM_006404
Angiogenesis
 211924_s_atPlasminogen activator, urokinase receptorPLAUR/UPAR3.420.007NM_002659
 207329_atMatrix metallopeptidase 8 (neutrophil collagenase)MMP82.420.012NM_002424
 210512_s_atVascular endothelial growth factor AVEGFA2.010.003AF022375
 209959_atNuclear receptor subfamily 4, group A, member 3NR4A3/NOR15.69<0.001U12767
 208751_atN-Ethylmaleimide-sensitive factor attachment protein, alphaNAPA2.560.001XM_011527436
Vasculitis
 203887_s_atThrombomodulinTHBD2.000.015NM_000361
 206157_atPentraxin 3, longPTX32.220.001NM_002852
 218880_atFOS-like antigen 2FOSL2/FRA23.170.005NM_005253
Apoptosis
M97935_5_atSignal transducer and activator of transcription 1, 91 kDaSTAT12.260.001GU211347
200796_s_atMyeloid cell leukemia sequence 1 (BCL2-related)MCL18.02<0.001AF118124
200664_s_atDnaJ (Hsp40) homolog, subfamily B, member 1DNAJB1/HSP402.200.010NM_006145
208536_s_atBCL2-like 11 (apoptosis facilitator)BCL2L112.380.001NM_006538
213606_s_atRho GDP dissociation inhibitor (GDI) alphaARHGDIA2.30<0.001NM_001185077
219228_atZinc finger protein 331ZNF331/RITA2.500.004NM_018555
209722_s_atSerpin peptidase inhibitor, clade b (ovalbumin), member 9SERPINB92.030.001NM_004155
201631_s_atImmediate early response 3IER32.850.001NM_003897
201367_s_atZFP36 ring finger protein-like 2ZFP36L29.07<0.001NM_006887
Cell proliferation
201235_s_atBTG family, member 2BTG24.53<0.001U72649
205767_atEpiregulinEREG3.510.013NM_001432
214052_x_atProline-rich coiled-coil 2CPRRC2C/XTP23.11<0.001NM_015172
208701_atAmyloid beta (A4) precursor-like protein 2APLP22.64<0.001NM_001642
217494_s_atPhosphatase and tensin homolog pseudogene 1PTENP13.110.001AF040103

Bold characters indicate TH17-related genes.