Prevention of Cyclophosphamide-Induced Immunosuppression in Mice with the Antimicrobial Peptide Sublancin

Figure 3

Effect of sublancin on the macrophage phagocytic index employing the carbon clearance test (a) and cytokine mRNA expression in the spleen of immunosuppressed mice (b–d). NC (normal control) = mice were treated with saline; MC (model control) = mice were administered with cyclophosphamide 80 mg/kg/d via i.p. injection for 3 days and gavaged with saline for 7 days; sublancin (2.0, 4.0, and 8.0) = mice were administered with cyclophosphamide 80 mg/kg/d via i.p. injection for 3 days and gavaged with sublancin at 2.0, 4.0, or 8.0 mg/kg/d for 7 days, respectively; LH (10.0) = mice were administered with cyclophosphamide 80 mg/kg/d via i.p. injection for 3 days and gavaged with levamisole hydrochloride for 7 days. Values are expressed as means ± SEM of three (a) or six (b–d) animals. , , and compared with NC group. and compared with MC group.

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