A DNA-Methylated Sight on Autoimmune Inflammation Network across RA, pSS, and SLE

Figure 2

Identifying the differential methylation status of three AIDs in CpG islands and neighbor sites. (a) Distribution of methylation status in promoters and nonpromoters across SLE, RA, and pSS, and the proportion of that was calculated using Pearson’s chi-squared test; (b-c) Venn diagrams of DMPs in the sites of CpGs and the neighbors (shores and shelves) common to the three AIDs separately; (d) heat map of 43 overlapping DMPs located in CpG islands; (e) heat map of 72 overlapping DMPs located in neighbors, and the detailed results of the two heat maps were in Additional File 4. RA: rheumatoid arthritis; SLE: systemic lupus erythematosus; pSS: primary Sjögren’s syndrome.

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