Integrin α9 Suppresses Hepatocellular Carcinoma Metastasis by Rho GTPase Signaling

Figure 1

Analysis of ITGA9 expression in HCC tissues. (a) Analysis of ITGA9 expression in HCC mRNAseq data from the TCGA database () and 3 independent HCC microarray datasets from the GEO database (GSE25097, ; GSE54236, ; and GSE14520, ). Values are means ± SEM. . (b) Expression levels of ITGA9 in CNL tissues and HCC tissues by qPCR for 34 pairs of the CNL/HCC tissues from RJH. Values are means ± SEM. . (c) Representative images of ITGA9 immunohistochemical staining in 131 paired HCC and CNL tissues. Scale bars, 100 μm. (d) Graphical analyses of (c) showing the decreased ITGA9 level in HCC patients compared to the paired CNL. Score of CNL > HCC: 72.55% (), score of CNL = HCC: 27.45% (), and score of CNL < HCC: 0% ().

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