Review Article
Effect of Natural Compounds on NK Cell Activation
Table 1
The effect of natural compounds on NK cells.
| Substance name | Effect on NK cells | References |
| Genistein | Increased/decreased cytotoxicity | [56–60] | Curcumin | Increased NO production, increased cytotoxicity | [61–67] | Ginseng extract | Increased cytotoxicity and granzyme B expression | [68–71] | Garlic extract | Increased cytotoxicity and cell number | [72–74] | Resveratrol | Increased cytotoxicity, JNK, ERK1/2 MAP kinase activity, perforin and NKG2D expression, and IFN-γ production | [75–78] | Ashwagandha extract | Increased cell number and CD69 expression | [79–83] | Ingenol mebutate | PKC activation, impaired cytotoxicity, and degranulation | [84–87] | Kumquat pericarp extract | Increased cytotoxicity and IFN-γ production | [88–90] | Prostratin | PKC activation, increased NKG2D expression and antiviral activity, impaired degranulation, and cytokine production | [87, 91] | Lectins | Increased cytotoxicity | [92] | Polysaccharides | Increased cytotoxicity and proliferation | [93–95] |
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